Expression of CD44 and CD35 during normal and myelodysplastic erythropoiesis. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Laranjeira, Paula; Rodrigues, Raquel; Carvalheiro, Tiago; Constanço, Conceição; Vitória, Helena; Matarraz, Sergio; Trindade, Hélder; Órfão, Alberto; Paiva, Artur
• Is Part Of: Leukemia research. Volume 39:Issue 3(2015:Mar.)
• Page Start: 361
• Page End: 370
• Publication Date: 2015-03
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2014.12.009
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">CD35 is an early marker of CD34+ erythroid-committed precursors.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">CD35 is expressed before CD105 in CD34+ erythroid-committed precursors.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">MDS patients display overall increased expression of CD44.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Our data suggest that phenotypic alterations in MDS precede morphologic dysplasia.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">MDS patients with anemia show increased expression of CD117 vs. MDS without anemia.</p> </list-item> </list> </p> </sec> </abstract>