Exploring determinants of progression in Parkinson's disease. Is there a difference among Jewish ethnic groups?. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Orlev, Y.; Yahalom, G.; Cohen, O.S.; Elincx-Benizri, S.; Kozlova, E.; Inzelberg, R.; Goldbourt, U.; Hassin-Baer, S.
• Is Part Of: Parkinsonism & related disorders. Volume 21:Issue 3(2015)
• Page Start: 184
• Page End: 188
• Publication Date: 2015-03
• Subjects: Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2014.10.009
• Languages: English
• ISSNs: 1353-8020

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Introduction</title> <p id="abspara0010">Parkinson's disease (PD) displays an individually variable rate of progression, of which the underlying mechanisms are largely unknown, but may involve genetic factors. In this study, we aimed to explore the effect of ethnic origin on PD progression rate in Israeli Jews, as expressed by time from onset until reaching Hoehn and Yahr stage 3 (HY3).</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Consecutive patients with PD followed bi-annually at the Movement Disorders Institute at Sheba Medical Center, were included. Demographic data and clinical information, including age at PD onset (AO), H&Y staging, and family history of PD, were collected. Ethnicity was determined based on the parents' origin and was categorized as Ashkenazi Jews (AJ), Yemenite Jews (YJ), North African Jews (NAJ) and Oriental Jews (OJ) excluding YJ. Associations between the above variables and the time to HY3 were determined using Cox proportional hazards model. Survival curves were derived from the model.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Of 707 patients [430 males, AJ: 458, YJ: 37, NAJ: 75 and OJ: 137] included in the analysis, 343 had reached HY3. In a multivariate analysis, a longer time to HY3 was significantly associated with a younger AO (HR = 1.07, <italic>p</italic> < 0.001). YJ showed a significantly shorter time to HY3 compared to AJ and OJ, but not compared to NAJ. Time to HY3 was significantly shorter for NAJ than for OJ.</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">Jewish PD patients of Yemenite and North African origin may have a more rapid progression of PD, compared to those of Ashkenazi and Oriental origin, suggesting distinctive genetic influences.</p> </sec> </abstract>