CpG hypermethylation contributes to decreased expression of PTEN during acquired resistance to gefitinib in human lung cancer cell lines. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Maeda, Masashi; Murakami, Yuichi; Watari, Kosuke; Kuwano, Michihiko; Izumi, Hiroto; Ono, Mayumi
• Is Part Of: Lung cancer. Volume 87:Issue 3(2015:Mar.)
• Page Start: 265
• Page End: 271
• Publication Date: 2015-03
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.01.009
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">PTEN overexpression restored the sensitivity to EGFR-TKI in resistant cells.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">EGR-1 did not have a critical role in decreased expression of PTEN in gefitinib-resistant cells.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Demethylation of the <italic>PTEN</italic> promoter by 5AZA-CdR upregulated PTEN expression.</p> </list-item> </list> </p> </sec> </abstract>