Future options for ALK-positive non-small cell lung cancer. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Iacono, Daniela; Chiari, Rita; Metro, Giulio; Bennati, Chiara; Bellezza, Guido; Cenci, Matteo; Ricciuti, Biagio; Sidoni, Angelo; Baglivo, Sara; Minotti, Vincenzo; Crinò, Lucio
• Is Part Of: Lung cancer. Volume 87:Issue 3(2015:Mar.)
• Page Start: 211
• Page End: 219
• Publication Date: 2015-03
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2014.12.017
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Crizotinib and ceritinib are highly effective ALK-TKIs for <italic>ALK</italic>-rearranged NSCLC.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Assays other than FISH (IHC, RT-PCR) are being investigated for ALK testing.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Next-generation ALK-TKIs are predicted to overcome resistance to crizotinib.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Combination of targeted therapies hold out much promise for <italic>ALK</italic>-positive NSCLC.</p> </list-item> </list> </p> </sec> </abstract>