Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Yeo, Chang Dong; Park, Ki Hoon; Park, Chan Kwon; Lee, Sang Haak; Kim, Seung Joon; Yoon, Hyung Kyu; Lee, Youn Soo; Lee, Eun Jung; Lee, Kyo Young; Kim, Tae-Jung
• Is Part Of: Lung cancer. Volume 87:Issue 3(2015:Mar.)
• Page Start: 311
• Page End: 317
• Publication Date: 2015-03
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2015.01.004
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We determined the relationship IGF-1R expression and the response to EGFR-TKIs in patients harboring activating EGFR mutations.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Expression of IGF-1R was independently associated with shorter PFS in a response to EGFR-TKIs.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Patients with DM highly expressed IGF-1R in tumor tissues.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">DM was associated with a poor response to first-line TKI therapy.</p> </list-item> </list> </p> </sec> </abstract>