Bacterial flagellin induces IL-6 expression in human basophils. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Jeon, Jun Ho; Ahn, Ki Bum; Kim, Sun Kyung; Im, Jintaek; Yun, Cheol-Heui; Han, Seung Hyun
• Is Part Of: Molecular immunology. Volume 65:Issue 1(2015:May)
• Page Start: 168
• Page End: 176
• Publication Date: 2015-05
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.01.022
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0050"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Flagellin alone induces IL-6 production in the human basophils.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">TLR5 expression is expressed both on the surface and in the cytoplasm of human basophil cell-line KU812.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ERK, p38 kinase, PKA, and PKC are involved in the flagellin-induced IL-6 production in KU812.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Basophils might be involved in the inflammation by producing IL-6 in response to bacterial flagellin.</p> </list-item> </list> </p> </sec> </abstract>