Lipoprotein in the cell wall of Staphylococcus aureus is a major inducer of nitric oxide production in murine macrophages. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Kim, Nam Joong; Ahn, Ki Bum; Jeon, Jun Ho; Yun, Cheol-Heui; Finlay, B. Brett; Han, Seung Hyun
• Is Part Of: Molecular immunology. Volume 65:Issue 1(2015:May)
• Page Start: 17
• Page End: 24
• Publication Date: 2015-05
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.12.016
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0010"> <list-item id="lsti0005"> <label></label> <p id="par0005"> <italic>Staphylococcus aureus</italic>, but not the lipoprotein-deficient mutant, induces nitric oxide (NO) production in murine macrophages.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Loss of NO induction by the lipoprotein-deficient mutant is mediated through the decreased expression of inducible NO synthase (iNOS).</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">The lipoprotein-deficient mutant hardly stimulates Toll-like receptor 2 and its signaling pathways required for iNOS induction.</p> </list-item> </list> </p> </sec> </abstract>