Desialylation of airway epithelial cells during influenza virus infection enhances pneumococcal adhesion via galectin binding. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Nita-Lazar, Mihai; Banerjee, Aditi; Feng, Chiguang; Amin, Mohammed N.; Frieman, Matthew B.; Chen, Wilbur H.; Cross, Alan S.; Wang, Lai-Xi; Vasta, Gerardo R.
• Is Part Of: Molecular immunology. Volume 65:Issue 1(2015:May)
• Page Start: 1
• Page End: 16
• Publication Date: 2015-05
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2014.12.010
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We studied the role of galectins in pneumococcal adhesion in the lung upon influenza.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">After influenza, galectin-1 and -3 levels are increased in the bronchoalveolar space.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Viral and bacterial neuraminidases increase galectin binding to epithelial cells.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Galectin-1 and -3 bind to glycans from the influenza virus and pneumococcus.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Galectin-3 enhances pneumococcal adhesion to influenza-infected airway epithelium.</p> </list-item> </list> </p> </sec> </abstract>