Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly. Issue 1 (May 2015)

• Record Type: Journal Article
• Authors: Verschoor, Chris P.; Loukov, Dessi; Naidoo, Avee; Puchta, Alicja; Johnstone, Jennie; Millar, Jamie; Lelic, Alina; Novakowski, Kyle E.; Dorrington, Michael G.; Loeb, Mark; Bramson, Jonathan L.; Bowdish, Dawn M.E.
• Is Part Of: Molecular immunology. Volume 65:Issue 1(2015:May)
• Page Start: 148
• Page End: 156
• Publication Date: 2015-05
• Subjects: Immunochemistry -- Periodicals; Molecular biology -- Periodicals; Immunochemistry -- Periodicals; Allergy and Immunology -- Periodicals; Molecular Biology -- Periodicals; Immunochimie -- Périodiques; Biologie moléculaire -- Périodiques; Immunochemistry; Molecular biology; Periodicals; Electronic journals; 571.96
• DOI: 10.1016/j.molimm.2015.01.015
• Languages: English
• ISSNs: 0161-5890

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Blood neutrophils appear basally activated and are immature in the advanced-age, frail elderly.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">CD11b and HLA-DR expression is related to the levels of circulating TNF and mtDNA in humans.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Loss of TNF in mice abrogates age-related increases in neutrophil CD11b <italic>in vivo.</italic></p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">mtDNA is able to induce neutrophil HLA-DR in a dose-dependent fashion <italic>ex vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>