Biomechanical evaluation of a novel suturing scheme for grafting load-bearing collagen scaffolds for rotator cuff repair. Issue 7 (August 2015)

• Record Type: Journal Article
• Authors: Islam, Anowarul; Bohl, Michael S.; Tsai, Andrew G.; Younesi, Mousa; Gillespie, Robert; Akkus, Ozan
• Is Part Of: Clinical biomechanics. Volume 30:Issue 7(2015)
• Page Start: 669
• Page End: 675
• Publication Date: 2015-08
• Subjects: Biomechanics -- Periodicals; Osteopathic medicine -- Periodicals; Biomechanics -- Periodicals; Osteopathic Medicine -- Periodicals; 612.76
• DOI: 10.1016/j.clinbiomech.2015.05.007
• Languages: English
• ISSNs: 0268-0033

Abstract

<abstract abstract-type="author" id="ab0005"> <title id="st0005">Abstract</title> <sec> <title id="st0010">Background</title> <p id="sp0005">Currently, there are no well-established suture protocols to attach fully load-bearing scaffolds which span tendon defects between bone and muscle for repair of critical sized tendon tears. Methods to attach load-bearing tissue repair scaffolds could enable functional repair of tendon injuries.</p> </sec> <sec> <title id="st0015">Methods</title> <p id="sp0010">Sixteen rabbit shoulders were dissected (New Zealand white rabbits, 1 yr. old, female) to isolate the humeral–infraspinatus muscle complex. A unique suture technique was developed to allow for a 5 mm segmental defect in infraspinatus tendon to be replaced with a mechanically strong bioscaffold woven from pure collagen threads. The suturing pattern resulted in a fully load-bearing scaffold. The tensile stiffness and strength of scaffold repair were compared with intact infraspinatus and regular direct repair.</p> </sec> <sec> <title id="st0020">Findings</title> <p id="sp0015">The failure load and displacement at failure of the scaffold repair group were 59.9 N (standard deviation, SD = 10.7) and 10.3 mm (SD = 2.9), respectively and matched those obtained by direct repair group which were 57.5 N (SD = 15.3) and 8.6 mm (SD = 1.5), (<italic>p</italic> > 0.05). Failure load, displacement at failure and stiffness of both of the repair groups were half of the intact infraspinatus shoulder group.</p> </sec> <sec> <title id="st0025">Interpretation</title> <p id="sp0020">With the developed suture technique, scaffold repair showed similar failure load, displacement at failure and stiffness to the direct repair. This novel suturing pattern and the mechanical robustness of the scaffold at time zero indicates that the proposed model is mechanically viable for future <italic>in vivo</italic> studies which has a higher potential to translate into clinical uses.</p> </sec> </abstract>