Endoplasmic reticulum stress and oxidative stress are involved in ZnO nanoparticle-induced hepatotoxicity. Issue 1 (2nd April 2015)

• Record Type: Journal Article
• Authors: Yang, Xia; Shao, Huali; Liu, Weirong; Gu, Weizhong; Shu, Xiaoli; Mo, Yiqun; Chen, Xuejun; Zhang, Qunwei; Jiang, Mizu
• Is Part Of: Toxicology letters. Volume 234:Issue 1(2015)
• Page Start: 40
• Page End: 49
• Publication Date: 2015-04-02
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.02.004
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0075"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Administration orally with ZnO nanoparticles (Nano-ZnO) caused disruption of ER structure and function in hepatocytes, resulting in ER stress.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Nano-ZnO also caused ER stress-associated genes and proteins upregulation and hepatocyte apoptosis.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">ER stress may be involved in Nano-ZnO-induced liver injury.</p> </list-item> </list> </p> </sec> </abstract>