P-Cresol mediates autophagic cell death in renal proximal tubular cells. Issue 1 (2nd April 2015)

• Record Type: Journal Article
• Authors: Lin, Hsin-Hung; Huang, Chiu-Ching; Lin, Tze-Yi; Lin, Ching-Yuang
• Is Part Of: Toxicology letters. Volume 234:Issue 1(2015)
• Page Start: 20
• Page End: 29
• Publication Date: 2015-04-02
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.02.003
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0035"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005"> <italic>p</italic>-Cresol (PC), a uremic toxin, decreases proliferation of renal proximal tubular cells (RPTC).</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">PC induces autophagy in RPTC through c-Jun activation mediated p62 accumulation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">PC promotes autophagic cell death in RPTC <italic>via</italic> caspase 8, followed by caspase 3 activation, which participates significantly to cell apoptosis.</p> </list-item> </list> </p> </sec> </abstract>