High content analysis: A sensitive tool to detect and quantify the cytotoxic, synergistic and antagonistic effects of chemical contaminants in foods. Issue 3 (18th March 2015)

• Record Type: Journal Article
• Authors: Clarke, R.; Connolly, L.; Frizzell, C.; Elliott, C.T.
• Is Part Of: Toxicology letters. Volume 233:Issue 3(2015)
• Page Start: 278
• Page End: 286
• Publication Date: 2015-03-18
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2015.01.011
• Languages: English
• ISSNs: 0378-4274

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0030"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">High content analysis (HCA) is a useful tool to determine cytotoxicity of complex mixtures.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Conventional endpoints MTT and NR were compared to HCA endpoints.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Tertiary mycotoxin mixture (OTA/FB1/AFB1) revealed more cytotoxicity using HCA endpoints over conventional endpoints.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Binary combination (OTA/FB1) revealed synergistic interactions using HCA previously undetected by conventional endpoints.</p> </list-item> </list> </p> </sec> </abstract>