Emerging potential of natural products for targeting mucins for therapy against inflammation and cancer. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Macha, Muzafar A.; Krishn, Shiv Ram; Jahan, Rahat; Banerjee, Kasturi; Batra, Surinder K.; Jain, Maneesh
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 3(2015)
• Page Start: 277
• Page End: 288
• Publication Date: 2015-03
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.01.001
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="graphical" id="ab005"> <title id="st100">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0200">Deregulated mucin expression is a hallmark of inflammation and cancer.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0205">Due to their functional involvement, mucins are potential therapeutic targets for cancer and inflammatory disorders.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0210">Inflammatory and oncogenic signaling networks that result in deregulated mucin expression have been characterized.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0215">Natural products are potential mucomodulators as they can modulate signaling pathways involved in mucin dysregulation.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0220">Recently several natural products have been demonstrated to modulate mucin expression and function <italic>in vitro</italic> and <italic>in vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>