Targeting specific molecular pathways holds promise for advanced gallbladder cancer therapy. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Bizama, Carolina; García, Patricia; Espinoza, Jaime A.; Weber, Helga; Leal, Pamela; Nervi, Bruno; Roa, Juan Carlos
• Is Part Of: Cancer treatment reviews. Volume 41:Issue 3(2015)
• Page Start: 222
• Page End: 234
• Publication Date: 2015-03
• Subjects: Cancer -- Periodicals; Cancer -- Treatment -- Periodicals; Neoplasms -- therapy -- Periodicals; Cancer -- Périodiques; Cancer -- Traitement -- Périodiques; Cancer -- Treatment; Electronic journals; Periodicals; 616.99406
• DOI: 10.1016/j.ctrv.2015.01.003
• Languages: English
• ISSNs: 0305-7372

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab010"> <title id="st175">Highlights</title> <sec> <p id="sp0030"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0315">Advanced gallbladder cancer has poor prognosis and inherent resistance to adjuvant therapy.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0320">The genetic and epigenetic alterations play an important role in gallbladder carcinogenesis.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0325">Emergent signaling pathways in GBC must be explored in order to design rational therapies.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0330">The use the inhibitors of oncogenic pathways is a promising therapeutic alternative in GBC.</p> </list-item> </list> </p> </sec> </abstract>