Kidney microcirculation response to adenosine stimulation in renal artery stenosis. (October 2015)

• Record Type: Journal Article
• Authors: Protasiewicz, Marcin; Początek, Karol; Podgórski, Maciej; Poręba, Rafał; Derkacz, Arkadiusz; Gosławska, Katarzyna; Kwiatkowska, Wiesława; Mazur, Grzegorz; Mysiak, Andrzej; Januszewicz, Andrzej
• Is Part Of: Blood pressure. Volume 24:Number 5(2015)
• Page Start: 293
• Page End: 297
• Publication Date: 2015-10
• Subjects: Blood pressure -- Periodicals; Hypertension -- Periodicals; Hypertension -- Periodicals; Blood Pressure -- Periodicals; 612.14
• DOI: 10.3109/08037051.2015.1053205
• Languages: English
• ISSNs: 0803-7051

Abstract

<abstract> <title>Abstract</title> <p>The purpose of this study was to assess the vasoconstrictive effects of adenosine in the kidney microcirculation in hypertensive patients with renal artery stenosis (RAS). Twelve patients with resistant hypertension and moderate RAS were selected for the study. In all patients, systolic, diastolic and mean translesional pressure gradients, distal pressure (<italic>Pd</italic>), aortic pressure (<italic>Pa</italic>) and <italic>Pd</italic>/<italic>Pa</italic> ratio were measured using a pressure guidewire at baseline and after intrarenal bolus administration of 400 μg adenosine. We observed significant changes in mean translesional pressure gradient and systolic <italic>Pd</italic> after pharmacological stimulation. The results suggest that in hypertensive patients with RAS, vasomotor activity of the kidney microcirculation may be preserved.</p> </abstract>