An Expedient Approach for the Synthesis of Bioactive Pyrazole, Isoxazole and Benzodiazepine‐Substituted Quinolin‐2(1H)‐one Derivatives. (16th June 2014)

• Record Type: Journal Article
• Authors: Sankaran, Mathan; Uvarani, Chokkalingam; Chandraprakash, Kumarasamy; Umamaheswari, Mani; Mohan, Palathurai Subramaniam
• Is Part Of: Journal of heterocyclic chemistry. Volume 52:Number 4(2015)
• Page Start: 1082
• Page End: 1092
• Publication Date: 2014-06-16
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.2192
• Languages: English
• ISSNs: 0022-152X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>A sequence of functionalized pyrazole, isoxazole and benzodiazepine‐substituted quinolone derivatives were synthesized in good yield starting from readily available starting precursors. These approaches lead to the synthesis of hitherto unknown compounds with a varied substitution pattern by both conventional and microwave‐assisted method. A good number of analogues were evaluated for their <italic>in vitro</italic> cytotoxicity against human cervical and colon cancer cell lines by MTT protocol. Almost all the selected compounds showed remarkable cytotoxic activities. Among them, compound <bold>4g</bold> and <bold>4i</bold> emerged as the most promising scaffolds. These scaffolds will be used for further molecular level studies.</p> </abstract>