Asymmetric Construction of Spirooxindoles by Organocatalytic Multicomponent Reactions Using Diazooxindoles1. Issue 32 (2nd July 2015)

• Record Type: Journal Article
• Authors: Wu, Ming‐Yue; He, Wei‐Wei; Liu, Xin‐Yuan; Tan, Bin
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 32(2015)
• Page Start: 9409
• Page End: 9413
• Publication Date: 2015-07-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201504640
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The first highly diastereo‐ and enantioselective multicomponent reaction of diazooxindoles, nitrosoarenes, and nitroalkenes using a newly developed hydrogen‐bond catalyst has been successfully developed for the efficient construction of a series of spirooxindole derivatives with excellent functional‐group tolerance. Spirooxindoles are formed in excellent yields and stereoselectivities, and the method represents an unprecedented approach for trapping the active intermediate with a nitroalkene to form biologically important compounds having three contiguous stereogenic centers with excellent asymmetric induction.</p> </abstract>