Rhodium(III)‐Catalyzed Activation of C sp 3H Bonds and Subsequent Intermolecular Amidation at Room Temperature1. Issue 32 (15th July 2015) - Huang, Xiaolei
Abstract Disclosed herein is a RhIII‐catalyzed chelation‐assisted activation of unreactive C sp 3H bonds, thus enabling an intermolecular amidation to provide a practical and step‐economic route to 2‐(pyridin‐2‐yl)ethanamine derivatives. Substrates with other N‐donor groups are also compatible with the amidation. This protocol proceeds at room temperature, has a relatively broad functional‐group tolerance and high selectivity, and demonstrates the potential of rhodium(III) in the promotive functionalization of unreactive C sp 3H bonds. A rhodacycle having a SbF6− counterion was identified as a plausible intermediate.