The structure–activity relationship of some hexacoordinated dimethyltin(IV) complexes of fluorinated β‐diketone/β‐diketones and sterically congested heterocyclic β‐diketones. (2nd June 2015)

• Record Type: Journal Article
• Authors: Sharma, Arti; Jain, Asha; Saxena, Sanjiv
• Is Part Of: Applied organometallic chemistry. Volume 29:Number 8(2015:Aug.)
• Page Start: 499
• Page End: 508
• Publication Date: 2015-06-02
• Subjects: Organometallic chemistry -- Periodicals; Organometallic compounds -- Periodicals; 547.05
• DOI: 10.1002/aoc.3321
• Languages: English
• ISSNs: 0268-2605

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The study was focused on the <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">structure–activity relationship</named-content> of some newly synthesized hexacoordinated dimethyltin(IV) complexes of fluorinated β‐diketone/β‐diketones and sterically congested heterocyclic β‐diketones. These complexes were screened for their <named-content content-type="chemicalTechnology" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">antibacterial activity</named-content> against a Gram‐negative bacterium (<italic>Pseudomonas aeruginosa</italic>) and Gram‐positive bacteria (<italic>Streptomyces griseus</italic>, <italic>Staphylococcus aureus</italic>, <italic>Bacillus subtilis</italic>) and the results were compared with those of a standard antibacterial drug. Some of the complexes were also screened for their antifungal activity against various fungi (<italic>Aspergillus niger</italic>, <italic>A</italic>. <italic>flavus</italic>, <italic>Trichoderma viride</italic>, <italic>Fusarium oxysporum</italic>) and were found to be active. These new hexacoordinated complexes of dimethyltin(IV) were generated by reactions of dimethyltin(IV) dichloride and sodium salts of fluorinated β‐diketone/β‐diketones and sterically congested heterocyclic β‐diketones in 1:1:1 molar ratio in refluxing dry benzene. Plausible structures of these complexes were suggested with the aid of physicochemical and spectroscopic studies. <sup>119</sup>Sn NMR spectral data revealed the presence of a hexacoordinated tin centre in these dimethyltin(IV) complexes. Copyright © 2015 John Wiley & Sons, Ltd.</p> </abstract>