Patch test results in children and adolescents across Europe. Analysis of the ESSCA Network1 2002–2010. Issue 5 (5th June 2015)

• Record Type: Journal Article
• Authors: Belloni Fortina, Anna; Cooper, Susan M.; Spiewak, Radoslaw; Fontana, Elena; Schnuch, Axel; Uter, Wolfgang; Aberer, Werner; Bircher, Andreas; Simon, Dagmar; Ballmer‐Weber, Barbara; Frosch, Peter; Fuchs, Thomas; Brasch, Jochen; Bauer, Andrea; Elsner, Peter; John, Swen Malte; Mahler, Vera; Weisshaar, Elke; Johansen, Jeanne Duus; Arnau, Ana Giménez; Sánchez‐Pérez, Javier; Silvestre, Juan Fco.; García‐Gavín, Juan; Fernández‐Redondo, Virginia; Amario‐Hita, José Carlos; Rantanen, Tapio; Ayala, Fabio; Balato, Anna; Peserico, Andrea; Filon, Francesca Larese; Wallnofer, W.; Corradin, Maria Teresa; Gallo, Rosella; Coenraads, Pieter‐Jan; Schuttelaar, Marie‐Louise; Rustemeyer, Thomas; Krecicz, Beata; Kieć‐Świerczyńska, Marta; Czarnecka‐Operacz, Magdalena; Sadowska, Anna; Dugonik, Aleksandra; Pandurovic, Maja Kalac; Kmecl, Tanja; Vok, Marko; Orton, David I.; Green, Cathy M.; Wilkinson, Mark; Sansom, Jane E.; King, Codagh M.; Horne, Helen L.; English, John S.C.; Graham, Johnston; Statham, Barry N.; Chowdhury, Mahbub M.U.; Stone, Natalie; Cooper, Sue; Gawkrodger, David J.; Ormerod, Anthony D.;
• Is Part Of: Pediatric allergy and immunology. Volume 26:Issue 5(2015)
• Page Start: 446
• Page End: 455
• Publication Date: 2015-06-05
• Subjects: Allergy in children -- Periodicals; Immunologic diseases in children -- Periodicals; 617
• DOI: 10.1111/pai.12397
• Languages: English
• ISSNs: 0905-6157

Abstract

<abstract abstract-type="main" id="pai12397-abs-0001"> <title>Abstract</title> <sec id="pai12397-sec-0001" sec-type="section"> <title>Background</title> <p>Contact sensitization in children is more frequent than previously thought.</p> </sec> <sec id="pai12397-sec-0002" sec-type="section"> <title>Methods</title> <p>The ESSCA collected patch test data from 11 European countries aggregated to 4 European regions.</p> </sec> <sec id="pai12397-sec-0003" sec-type="section"> <title>Results</title> <p>Six thousand and eight patients aged 1–16 years old with suspected allergic contact dermatitis were analyzed during a period of 8 years (2002–2010). The overall prevalence of at least one positive reaction to a hapten was 36.9%. The 10 most frequent haptens were as follows: nickel sulfate, cobalt chloride and potassium dichromate, neomycin sulfate, <italic>Myroxylon pereirae</italic> resin (balsam of Peru), para‐phenylenediamine, chloromethylisothiazolinone/methylisothiazolinone 3:1, fragrance mix, lanolin alcohols, and colophony. No difference was found in the prevalence of at least one positive reaction to at least one hapten between boys and girls and between children with atopic dermatitis and children without. Children without atopic dermatitis, when compared with those with, had a significantly higher prevalence of contact sensitization for nickel sulfate (20.91% vs 16.87%, respectively), 4‐tert. butylphenol formaldehyde resin (1.61% vs. 0.7%), and para‐phenylenediamine (2.49% vs. 1.3%).</p> </sec> <sec id="pai12397-sec-0004" sec-type="section"> <title>Limitations of the study</title> <p>Chamber loading is not an exact science and variation may occur between staff and departments. Interinstitution variations in readings can occur. A possible geographic confounder is that the southern regions tested more children in the younger age group. Relevance was not addressed due to difficulties in the application of a set of uniform definitions.</p> </sec> <sec id="pai12397-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Our study adds information on the most common contact allergens detected in children which could help to define a Standard European <italic>Pediatric</italic> Baseline Series.</p> </sec> </abstract>