Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. Issue 9 (September 2015)

• Record Type: Journal Article
• Authors: Abe, Hiroshi; Aida, Yuta; Seki, Nobuyoshi; Sugita, Tomonori; Tomita, Yoichi; Nagano, Tomohisa; Itagaki, Munenori; Sutoh, Satoshi; Nagatsuma, Keisuke; Itoh, Kyoko; Matsuura, Tomokazu; Aizawa, Yoshio
• Is Part Of: Journal of gastroenterology and hepatology. Volume 30:Issue 9(2015:Sep.)
• Page Start: 1376
• Page End: 1383
• Publication Date: 2015-09
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; Gastroenterology -- Periodicals; Liver Diseases -- Periodicals; 616.33
• DOI: 10.1111/jgh.12948
• Languages: English
• ISSNs: 0815-9319

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jgh12948-sec-0001" sec-type="section"> <title>Background and Aim</title> <p>We aimed to clarify the influences of aldehyde dehydrogenase 2 (<italic>ALDH2</italic>), alcohol dehydrogenase 1B (<italic>ADH1B</italic>) polymorphisms, and ethanol consumption profile to hepatocellular carcinoma (HCC) development in alcoholic liver cirrhosis without chronic hepatitis B and C virus infection (non‐B non‐C).</p> </sec> <sec id="jgh12948-sec-0002" sec-type="section"> <title>Methods</title> <p>Of 236 freshly diagnosed non‐B non‐C alcoholic liver cirrhosis patients, 67 were diagnosed as HCC and the remaining 169 as not having HCC. The relationship between the genetic polymorphisms and development to HCC were evaluated in well‐matched patients with HCC (HCC group, <italic>n</italic> = 67) and without HCC (non‐HCC group, <italic>n</italic> = 67) using propensity scores in age, sex, and prevalence of diabetes mellitus.</p> </sec> <sec id="jgh12948-sec-0003" sec-type="section"> <title>Results</title> <p>Daily amount of ethanol consumption was significantly lower (<italic>P</italic> = 0.005), and consumptive period was significantly longer (<italic>P</italic> = 0.003) in HCC group than non‐HCC group. Of 134 well‐matched patients, 113 (84.3%) had <italic>ALDH2</italic><italic>*1/*1</italic> genotype and 21 (15.7%) had <italic>ALDH2</italic><italic>*1/*2</italic> genotype. In HCC development, consumptive long period (<italic>P</italic> = 0.007) and carrying <italic>ALDH2</italic><italic>*1/*2</italic> genotype (<italic>P</italic> = 0.026) were identified as significant factors independently participated, while there was no relation to <italic>ADH1B</italic> polymorphism. In addition, consumptive period was significantly longer in HCC group than non‐HCC group in <italic>ALDH2</italic><italic>*1/*1</italic> genotype patients (<italic>P</italic> = 0.0005), while there was no difference in profile of ethanol consumption in <italic>ALDH2</italic><italic>*1/*2</italic> genotype patients. Among HCC group, daily (<italic>P</italic> = 3.78 × 10<sup>−6</sup>) and cumulative amount (<italic>P</italic> = 4.89 × 10<sup>−6</sup>) of ethanol consumption were significantly higher in <italic>ALDH2</italic><italic>*1/*1</italic> genotype patients than <italic>ALDH2</italic><italic>*1/*2</italic> genotype patients.</p> </sec> <sec id="jgh12948-sec-0004" sec-type="section"> <title>Conclusion</title> <p>In alcoholic liver cirrhosis, investigations of <italic>ALDH2</italic> polymorphism and ethanol consumption profile are useful for prediction of HCC development.</p> </sec> </abstract>