Change of carotid intima‐media thickness is associated with age in elderly Japanese patients without a history of cardiovascular disease. Issue 8 (14th October 2014)

• Record Type: Journal Article
• Authors: Watanabe, Kentaro; Ouchi, Motoshi; Ohara, Makoto; Kameda, Wataru; Susa, Shinji; Oizumi, Toshihide; Wada, Manabu; Suzuki, Tatsuya; Kawanami, Toru; Oba, Kenzo; Kato, Takeo
• Is Part Of: Geriatrics and gerontology international. Volume 15:Issue 8(2015)
• Page Start: 1023
• Page End: 1030
• Publication Date: 2014-10-14
• Subjects: Geriatrics -- Periodicals; Gerontology -- Periodicals; Geriatrics -- Japan -- Periodicals; Gerontology -- Japan -- Periodicals; 618.97
• DOI: 10.1111/ggi.12402
• Languages: English
• ISSNs: 1444-1586

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ggi12402-sec-0001" sec-type="section"> <title>Aim</title> <p>The present study aimed to evaluate the relationship between the change of carotid intima‐media thickness (CIMT) and clinical characteristics in Japanese patients without a history of cardiovascular disease.</p> </sec> <sec id="ggi12402-sec-0002" sec-type="section"> <title>Methods</title> <p>The study participants were 149 Japanese patients without a history of cardiovascular disease treated in our outpatient department. The in all participants CIMT was measured with ultrasonography at baseline and after a mean interval of 2.4 years. Study participants were divided into a middle‐aged group (younger than 65 years: <italic>n</italic> = 59) and an elderly group (65 years or older: <italic>n</italic> = 90). The annual CIMT change (ΔCIMT) was calculated, and the associations between ΔCIMT and clinical characteristics, including age, were evaluated in both groups.</p> </sec> <sec id="ggi12402-sec-0003" sec-type="section"> <title>Results</title> <p>The ΔCIMT was significantly correlated with age in all participants (<italic>r</italic> = 0.222; <italic>P</italic> < 0.05) and in elderly participants (r = 0.234; <italic>P</italic> < 0.05), but was not correlated with other risk factors. The annual ΔCIMT was significantly higher in elderly participants (0.015 ± 0.096 mm) than in middle‐aged participants (–0.018 ± 0.088 mm; <italic>P</italic> < 0.05). Multivariate linear regression analysis with ΔCIMT as a dependent variable and risk factors as independent variables showed that ΔCIMT was significantly associated with age in all participants (β = 0.002; <italic>P</italic> < 0.05) and in elderly participants (β = 0.004; <italic>P</italic> < 0.05), but not with other risk factors.</p> </sec> <sec id="ggi12402-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Annual CIMT change is associated with age, rather than with other clinical characteristics, including traditional cardiovascular risk factors, such as diabetes and hypertension, in elderly Japanese patients without a history of cardiovascular disease. <bold>Geriatr Gerontol Int 2015; 15: 1023–1030.</bold></p> </sec> </abstract>