Less noise, more activation: Multiband acquisition schemes for auditory functional MRI. Issue 2 (8th August 2014)

• Record Type: Journal Article
• Authors: De Martino, Federico; Moerel, Michelle; Ugurbil, Kamil; Formisano, Elia; Yacoub, Essa
• Is Part Of: Magnetic resonance in medicine. Volume 74:Issue 2(2015:Aug.)
• Page Start: 462
• Page End: 467
• Publication Date: 2014-08-08
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.25408
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm25408-sec-0001" sec-type="section"> <title>Purpose</title> <p>To improve acquisition in fMRI studies of audition by using multiband (MB) gradient‐echo echo planar imaging (GE‐EPI).</p> </sec> <sec id="mrm25408-sec-0002" sec-type="section"> <title>Methods</title> <p>Data were acquired at 3T (Siemens Skyra) with a 32‐channel head coil. Functional responses were obtained by presenting stimuli [tones and natural sounds (voices, speech, music, tools, animal cries)] in silent gaps between image acquisitions. Two‐fold slice acceleration (MB2) was compared with a standard GE‐EPI (MB1). Coverage and sampling rate (TR = 3 s) were kept constant across acquisition schemes. The longer gap in MB2 scans was used to present: (i) sounds of the same length as in conventional GE‐EPI (type 1; 800 ms stimuli); (ii) sounds of double the length (type 2; 1600 ms stimuli).</p> </sec> <sec id="mrm25408-sec-0003" sec-type="section"> <title>Results</title> <p>Functional responses to all sounds (i.e., main effect) were stronger when acquired with slice acceleration (i.e., shorter acquisition time). The difference between voice and nonvoice responses was greater in MB2 type 1 acquisitions (i.e., same length sounds as GE‐EPI but presented in a longer silent gap) than in standard GE‐EPI acquisitions (interaction effect).</p> </sec> <sec id="mrm25408-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Reducing the length of the scanner noise results in stronger functional responses. Longer "silent" periods (i.e., keeping the sound length the same as in standard acquisitions) result in stronger response to voice compared with nonvoice stimuli. Magn Reson Med 74:462–467, 2015. © 2014 Wiley Periodicals, Inc.</p> </sec> </abstract>