Betamethasone augments the antifungal effect of menadione—towards a novel anti‐Candida albicans combination therapy. (24th February 2015)

• Record Type: Journal Article
• Authors: Jakab, Ágnes; Emri, Tamás; Sipos, Lilla; Kiss, Ágnes; Kovács, Renátó; Dombrádi, Viktor; Kemény‐Beke, Ádám; Balla, József; Majoros, László; Pócsi, István
• Is Part Of: Journal of basic microbiology. Volume 55:issue 8(2015:Aug.)
• Page Start: 973
• Page End: 981
• Publication Date: 2015-02-24
• Subjects: Microbiology -- Periodicals; 579
• DOI: 10.1002/jobm.201400903
• Languages: English
• ISSNs: 0233-111X

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jobm201400903-sec-0001" sec-type="section"> <p>The fluorinated glucocorticoid betamethasone stimulated both the extracellular phospholipase production and hypha formation of the opportunistic human pathogen <italic>Candida albicans</italic> and also decreased the efficiency of the polyene antimycotics amphotericin B and nystatin against <italic>C. albicans</italic> in a dose‐dependent manner. Importantly, betamethasone increased synergistically the anti‐<italic>Candida</italic> activity of the oxidative stress generating agent menadione, which may be exploited in future combination therapies to prevent or cure <italic>C. albicans</italic> infections, in the field of dermatology.</p> </sec> </abstract>