Serum cardiac troponin I concentrations decrease following treatment of primary immune‐mediated haemolytic anaemia. (2nd July 2015)

• Record Type: Journal Article
• Authors: Cartwright, J. A.; Gow, D. J.; Gow, A. G.; Handel, I.; Reed, N.; Brown, A. J.; Cash, R.; Foote, A.; Mackenzie, D.; Bell, R.; Mellanby, R. J.
• Is Part Of: Journal of small animal practice. Volume 56:Number 8(2015:Aug.)
• Page Start: 516
• Page End: 520
• Publication Date: 2015-07-02
• Subjects: Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; 636.089
• DOI: 10.1111/jsap.12379
• Languages: English
• ISSNs: 0022-4510

Abstract

<abstract abstract-type="main" id="jsap12379-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jsap12379-sec-0001" sec-type="section"> <title>OBJECTIVES</title> <p id="jsap12379-para-0001">The measurement of serum cardiac troponin I concentrations in dogs with a range of non‐primary cardiac illnesses suggests that cardiac myocyte damage is commonplace. Dogs with primary immune‐mediated haemolytic anaemia have increased serum cardiac troponin I concentrations at the time of diagnosis. However, it is unclear whether biochemical evidence of cardiac myocyte damage improves following successful treatment of anaemia.</p> </sec> <sec id="jsap12379-sec-0002" sec-type="section"> <title>METHODS</title> <p id="jsap12379-para-0002">A haematology profile was performed and serum cardiac troponin I concentrations were measured in 19 dogs with primary immune‐mediated haemolytic anaemia before and after treatment.</p> </sec> <sec id="jsap12379-sec-0003" sec-type="section"> <title>RESULTS</title> <p id="jsap12379-para-0003">The haematocrit increased significantly (P = 0 · 0001) following treatment of primary IMHA (median pre: 0 · 13 L/L, median post: 0 · 33 L/L). The serum cardiac troponin I concentrations decreased significantly (P < 0 · 05) after treatment (median pre: 0 · 26 ng/mL, median post: 0 · 16 ng/mL).</p> </sec> <sec id="jsap12379-sec-0004" sec-type="section"> <title>CLINICAL SIGNIFICANCE</title> <p id="jsap12379-para-0004">Serum cardiac troponin I concentration decreases following successful treatment of primary immune‐mediated haemolytic anaemia. The clinical and prognostic significance of serum cardiac troponin I concentrations before and after treatment in dogs with primary immune‐mediated haemolytic anaemia merits further investigation.</p> </sec> </abstract>