Depression: Cognition relations after stroke. Issue 6 (27th October 2013)

• Record Type: Journal Article
• Authors: Hommel, Marc; Carey, Leeanne; Jaillard, Assia
• Is Part Of: International journal of stroke. Volume 10:Issue 6(2015:Aug.)
• Page Start: 893
• Page End: 896
• Publication Date: 2013-10-27
• Subjects: 616.8005
• DOI: 10.1111/ijs.12057
• Languages: English
• ISSNs: 1747-4930

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ijs12057-sec-0001" sec-type="section"> <title>Background</title> <p>Poststroke depression and cognitive dysfunction are common and are independent predictors of poor recovery.</p> </sec> <sec id="ijs12057-sec-0002" sec-type="section"> <title>Aims</title> <p>We assessed whether and how depression and cognition were correlated in the subacute period after stroke.</p> </sec> <sec id="ijs12057-sec-0003" sec-type="section"> <title>Method</title> <p>We prospectively recruited 207 nondemented patients (Mini Mental State Examination ≥ 23) presenting with a first‐ever ischemic stroke (127 males), mean age of 48·5 years (16·4 standard deviation), median 12 days after infarction, as assessed on magnetic resonance imaging. We administered a comprehensive neuropsychological battery involving cognitive domains including instrumental functions, memory, executive functions, and working memory. Depression was quantified with the Beck Depression Inventory.</p> </sec> <sec id="ijs12057-sec-0004" sec-type="section"> <title>Results</title> <p>Depression (Beck Depression Inventory > 9) was identified in 30·4% of the patients (95% confidence interval 24·2–37·2%). Median Beck Depression Inventory was 6. Median Mini Mental State Examination was 30. Cognitive dysfunctioning in at least one neuropsychological test was present in 89% (95% confidence interval 84–93%). Each point increase of Beck Depression Inventory was associated with an odd of 1·1 (95% confidence interval 1·04–1·19) of changing to a worse category of cognition. Stroke location was not correlated with depression. All cognitive domains were significantly correlated with depression. In multivariate analysis, the executive functions (<italic>P</italic> = 0·001) and the working memory (<italic>P</italic> = 0·009) were the best predictors of depression when adjusted for demographic and stroke characteristics.</p> </sec> <sec id="ijs12057-sec-0005" sec-type="section"> <title>Conclusions</title> <p>The rates of depression and cognitive impairment were in the range of previous stroke studies. Our study suggested a strong relation between depression and cognition characterized by executive functions and working memory dysfunctioning.</p> </sec> </abstract>