Conformational and Chiral Properties of Cyclic‐tri(N‐methyl‐meta‐benzamide) Bearing Amidino Groups. Issue 8 (24th June 2015)

• Record Type: Journal Article
• Authors: Nishiyama, Shizuka; Urushibara, Ko; Masu, Hyuma; Azumaya, Isao; Kagechika, Hiroyuki; Tanatani, Aya
• Is Part Of: Chirality. Volume 27:Issue 8(2015)
• Page Start: 487
• Page End: 491
• Publication Date: 2015-06-24
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22476
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>Cyclic triamides <bold>4</bold> bearing amidino groups at the meta position of the phenyl rings were synthesized, and their conformational properties in the crystal and in solution were examined. Compound <bold>4a</bold> exists as a capsule‐type dimer of the enantiomers with a bowl‐shaped syn conformation in the crystal state. Compound <bold>4</bold> exists mainly in the syn form in solution, and chiral induction was observed upon addition of a chiral acid to a solution of <bold>4a</bold>. <italic>Chirality 27:487–491, 2015</italic>. © 2015 Wiley Periodicals, Inc.</p> </abstract>