Black tea extract improves anti-oxidant profile in experimental diabetic rats. (July 2015)

• Record Type: Journal Article
• Authors: Kumar, Dileep; Rizvi, Syed Ibrahim
• Is Part Of: Archives of physiology and biochemistry. Volume 121:Number 3(2015)
• Page Start: 109
• Page End: 115
• Publication Date: 2015-07
• Subjects: Physiology -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Biochemistry; Physiology; 571
• DOI: 10.3109/13813455.2015.1043308
• Languages: English
• ISSNs: 1381-3455

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: The purpose of this study was to investigate the <italic>in vivo</italic> anti-oxidant effect of black tea extract (BTE) supplemented to normal and alloxan-induced diabetic rats. <italic>Methods</italic>: Black tea extract (BTE) was fed to control and experimental diabetic rats by gavage technique at a dose of 1 ml/100 g body weight/day. Markers of oxidative stress in blood were determined. <italic>Result</italic>: Results show a significant (<italic>P</italic> &lt; 0.01) decrease (73%) in plasma anti-oxidant potential, increase in activity of plasma membrane redox system (122%), protein oxidation and lipid peroxidation in diabetic rats, BTE supplemented diabetic rats had improved anti-oxidant profile and lower protein and lipid peroxidation levels. Diabetic rats displayed lower intracellular glutathione (GSH), BTE supplementation improved GSH levels. <italic>Conclusion</italic>: Results of this study suggest that the 2.5% aqueous extract of black tea is effective to ameliorate diabetes associated oxidative stress parameters in experimental model of diabetes.</p> </abstract>