Body mass index and progressive hand osteoarthritis: data from the Oslo hand osteoarthritis cohort. (July 2015)

• Record Type: Journal Article
• Authors: Magnusson, K; Slatkowsky-Christensen, B; van der Heijde, D; Kvien, TK; Hagen, KB; Haugen, IK
• Is Part Of: Scandinavian journal of rheumatology. Volume 44:Number 4(2015)
• Page Start: 331
• Page End: 336
• Publication Date: 2015-07
• Subjects: Rheumatology -- Periodicals; Arthritis; Rheumatic Diseases; 616.72005
• DOI: 10.3109/03009742.2014.994560
• Languages: English
• ISSNs: 0300-9742

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objectives:</bold> Few longitudinal studies have studied the association between body mass index (BMI) and hand osteoarthritis (OA). We aimed to explore the association between BMI and progressive hand OA in a longitudinal study of the Oslo hand OA cohort.</p> <p> <bold>Method:</bold> Participants with existing hand OA had hand radiographs and BMI data taken at baseline and 7-year follow-up (n = 103). The radiographs were read according to the Kellgren–Lawrence (KL) scale. First, we examined the association between baseline BMI and incident OA (KL grade ≥ 2) in joints without OA at baseline (adjusted for age and sex) using generalized estimating equation (GEE) analyses. Second, we examined whether changes in BMI from baseline to follow-up were associated with increasing KL sum score from baseline to follow-up using linear regression. We repeated the analyses using changes in number of joints with symptomatic OA and patient-reported pain and physical function as the outcome.</p> <p> <bold>Results:</bold> The mean (SD) age at baseline was 61.6 (5.6) years and 91 (94%) of the cohort were women. The mean (SD) BMI was 25.7 (4.0) kg/m<sup>2</sup> at baseline and the mean (SD) BMI change was 1.1 (2.0) kg/m<sup>2</sup>. There was no relationship between baseline BMI and development of more joints with OA during follow-up. Similarly, there was no association between change in BMI and hand OA progression, increasing hand pain or disability.</p> <p> <bold>Conclusions:</bold> In the Oslo hand OA cohort, higher BMI was not related to hand OA progression.</p> </abstract>