Association between cannabinoid receptor type 2 Q63R variant and oligo/polyarticular juvenile idiopathic arthritis. (July 2015)

• Record Type: Journal Article
• Authors: Bellini, G; Olivieri, AN; Grandone, A; Alessio, M; Gicchino, MF; Nobili, B; Perrone, L; Maione, S; Miraglia del Giudice, E; Rossi, F
• Is Part Of: Scandinavian journal of rheumatology. Volume 44:Number 4(2015)
• Page Start: 284
• Page End: 287
• Publication Date: 2015-07
• Subjects: Rheumatology -- Periodicals; Arthritis; Rheumatic Diseases; 616.72005
• DOI: 10.3109/03009742.2015.1020863
• Languages: English
• ISSNs: 0300-9742

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objectives:</bold> To investigate whether the functional variant Q63R of the cannabinoid 2 (CB2) receptor is associated with susceptibility to oligo/poly-articular juvenile idiopathic arthritis (JIA) and with its clinical features.</p> <p>Method: A total of 171 Italian children with oligoarticular/rheumatoid factor negative poly-articular JIA and 600 healthy controls were enrolled in the study and genotyped.</p> <p>Results: A significant difference in genotype distribution of the CB2 Q63R variant (<italic>CNR2</italic> rs35761398) between oligo/poly-articular JIA patients and controls was found (<italic>p</italic> = 0.001). The R63 variant was associated with increased rates of relapse (<italic>p</italic> = 0.0001).</p> <p> <bold>Conclusions:</bold> This study indicates that the CB2 receptor contributes to susceptibility to oligo/polyarticular JIA and to the severity of its clinical course.</p> </abstract>