The association between infectious burden and Parkinson's disease: A case-control study. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Bu, Xian-Le; Wang, Xin; Xiang, Yang; Shen, Lin-Lin; Wang, Qing-Hua; Liu, Yu-Hui; Jiao, Shu-Sheng; Wang, Ye-Ran; Cao, Hong-Yuan; Yi, Xu; Liu, Cheng-Hui; Deng, Bo; Yao, Xiu-Qing; Xu, Zhi-Qiang; Zhou, Hua-Dong; Wang, Yan-Jiang
• Is Part Of: Parkinsonism & related disorders. Volume 21:Issue 8(2015)
• Page Start: 877
• Page End: 881
• Publication Date: 2015-08
• Subjects: Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2015.05.015
• Languages: English
• ISSNs: 1353-8020

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Abstract</title> <sec> <title id="sectitle0015">Introduction</title> <p id="abspara0010">The etiology of Parkinson's disease (PD) remains unclear. The aim of this study was to examine the association between common pathogenic infections and PD.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Antibody titers to common infectious pathogens including cytomegalovirus (CMV), Epstein Barr virus (EBV)，herpes simplex virus type-1 (HSV-1), <italic>Borrelia burgdorferi</italic> (<italic>B. burgdorferi</italic>), <italic>Chlamydophila pneumoniae</italic> (<italic>C</italic>. <italic>pneumoniae</italic>) and <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) were measured by ELISA in serum of 131 PD patients and 141 normal controls. Infectious burden (IB) was defined as a composite serologic measure of exposure to these common pathogens.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Seropositivities toward zero-two, three-four and five-six of these pathogens were found in 11%, 74% and 15% of normal controls while in 4%, 61% and 35% of PD patients, respectively. IB, bacterial burden and viral burden were independently associated with PD. Schwab and England (S&E) scores were negatively correlated with IB in patients with PD. Serum α-synuclein protein levels and inflammatory cytokines (interleukin-1β and interleukin-6) in individuals with higher IB were also significantly higher.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">IB consisting of CMV, EBV, HSV-1, <italic>B. burgdorferi</italic>, <italic>C. pneumoniae</italic> and <italic>H. pylori</italic> is associated with PD. This study supports the role of infection in the etiology of PD.</p> </sec> </abstract>