Salvage endoscopic nasopharyngectomy is superior to intensity-modulated radiation therapy for local recurrence of selected T1–T3 nasopharyngeal carcinoma – A case-matched comparison. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: You, Rui; Zou, Xiong; Hua, Yi-Jun; Han, Fei; Li, Li; Zhao, Chong; Hong, Ming-Huang; Chen, Ming-Yuan
• Is Part Of: Radiotherapy and oncology. Volume 115:Issue 3(2015:Jun.)
• Page Start: 399
• Page End: 406
• Publication Date: 2015-06
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.04.024
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st005">Abstract</title> <sec> <title id="st010">Background</title> <p id="sp0005">Salvage ENPG and IMRT are more effective treatments for rNPC than traditional 2-dimensional radiotherapy. However, compared with IMRT, the benefits of ENPG have not yet been clearly described.</p> </sec> <sec> <title id="st015">Methods</title> <p id="sp0010">We defined a resectable area in which the disease could be radically removed using ENPG and our imaging specialists selected eligible patients with tumors confined to this resectable area from a database of rNPC patients. Using propensity scores to adjust for some potential prognostic factors, a well-balanced cohort of 144 limited rNPC patients was created by matching each patient who underwent ENPG (study group) with one who underwent IMRT (control group). Morbidity, long-term oncological results, treatment-related complications, medical costs, and quality of life were compared.</p> </sec> <sec> <title id="st020">Results</title> <p id="sp0015">Compared with IMRT, ENPG was associated with a relatively good overall survival (5-year OS, 77.1% vs 55.5%, <italic>P</italic> = .003), QOL conservation (mean global health status score, 57.6 vs 29.8, <italic>P</italic> < .001), and significant decreases in post-treatment complications (12.5% vs 65.3%, <italic>P</italic> < .001), medical costs (23 645.90 vs 118 122.53 Yuan, <italic>P</italic> < .001) ≈ (€2371.71 vs 11, 847.80, <italic>P</italic> < .001).</p> </sec> <sec> <title id="st025">Conclusions</title> <p id="sp0020">Salvage ENPG may be more effective for maximizing survival and QOL benefits and minimizing treatment-related complications and medical costs for limited rNPC patients, as compared with IMRT.</p> </sec> </abstract>