A multi-centre analysis of treatment procedures and error components in dynamic tumour tracking radiotherapy. Issue 3 (June 2015)

• Record Type: Journal Article
• Authors: Matsuo, Yukinori; Verellen, Dirk; Poels, Kenneth; Mukumoto, Nobutaka; Depuydt, Tom; Akimoto, Mami; Nakamura, Mitsuhiro; Ueki, Nami; Engels, Benedikt; Collen, Christine; Kokubo, Masaki; Hiraoka, Masahiro; de Ridder, Mark
• Is Part Of: Radiotherapy and oncology. Volume 115:Issue 3(2015:Jun.)
• Page Start: 412
• Page End: 418
• Publication Date: 2015-06
• Subjects: Oncology -- Periodicals; Radiotherapy -- Periodicals; Tumors -- Periodicals; Medical Oncology -- Periodicals; Neoplasms -- radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiothérapie -- Périodiques; Cancérologie -- Périodiques; Tumeurs -- Périodiques; Electronic journals; 616.9940642
• DOI: 10.1016/j.radonc.2015.05.003
• Languages: English
• ISSNs: 0167-8140

Abstract

<abstract xml:lang="en" abstract-type="author" id="ab005"> <title id="st085">Abstract</title> <sec> <title id="st090">Purpose</title> <p id="sp0005">This study aimed to compare procedures for dynamic tumour tracking (DTT) using a gimbal-mounted linac between centres in Japan (KU-IBRI) and Belgium (UZB), to quantify tracking error (TE), and to estimate tumour-fiducial uncertainties and PTV margins.</p> </sec> <sec> <title id="st095">Methods</title> <p id="sp0010">Twenty-two patients were evaluated. TE was divided into components originating from the patient, fraction, segment, and residuals.</p> </sec> <sec> <title id="st100">Results</title> <p id="sp0015">KU-IBRI applied DTT to lung cancer, while UZB treated both the lung and liver. Patients from UZB were younger and had a higher body mass index. DTT procedures differed in the use of body fixation, correction for set-up error, type of fiducial markers, and goodness of fit of correlation model. TE was larger at UZB in the intra-fraction components, whereas the tumour-fiducial uncertainties were estimated to be larger at KU-IBRI. These results ultimately led to similar PTV margins at both centres (2.1, 4.2, and 2.6 mm for KU-IBRI; 2.4, 3.6, and 2.0 mm for UZB in LR, AP, and SI, respectively, for 99% coverage of patients).</p> </sec> <sec> <title id="st105">Conclusion</title> <p id="sp0020">Several differences in procedures and patient characteristics were observed that affected TE and tumour-fiducial uncertainties. This analysis confirmed similar accuracy in DTT delivery and adequate PTV margins in the different centres based on their local specific workflows.</p> </sec> </abstract>