AS03-adjuvanted H7N1 detergent-split virion vaccine is highly immunogenic in unprimed mice and induces cross-reactive antibodies to emerged H7N9 and additional H7 subtypes. Issue 32 (31st July 2015)

• Record Type: Journal Article
• Authors: Mallett, Corey P.; Beaulieu, Edith; Joly, Marie-Hélène; Baras, Benoît; Lu, Xiuhua; Liu, Feng; Levine, Min Z.; Katz, Jacqueline M.; Innis, Bruce L.; Giannini, Sandra L.
• Is Part Of: Vaccine. Volume 33:Issue 32(2015)
• Page Start: 3784
• Page End: 3787
• Publication Date: 2015-07-31
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.06.053
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005">.<list id="lis0005"><list-item id="lsti0005"><label></label><p id="par0005">An investigational detergent-split H7N1vaccine adjuvanted with AS03 was immunogenic in mice down to nanogram levels of HA antigen per dose.</p></list-item><list-item id="lsti0010"><label></label><p id="par0010">The non-adjuvanted H7N1 vaccine was poorly immunogenic, which demonstrated the requirement of AS03 to induce robust antibody titers.</p></list-item><list-item id="lsti0015"><label></label><p id="par0015">The AS03-adjuvanted vaccine also induced robust antibody responses that cross-reacted with the recently emerged H7N9 and highly pathogenic H7N7 and H7N3 viruses.</p></list-item><list-item id="lsti0020"><label></label><p id="par0020">These preclinical data suggest that AS03 adjuvant technology may be effective for formulating antigen-sparing vaccines against avian influenza A virus subtypes such as H7.</p></list-item></list></p> </sec> </abstract>