Surrogate molecular markers for IGHV mutational status in chronic lymphocytic leukemia for predicting time to first treatment. Issue 8 (August 2015)

• Record Type: Journal Article
• Authors: Morabito, Fortunato; Cutrona, Giovanna; Mosca, Laura; D'Anca, Marianna; Matis, Serena; Gentile, Massimo; Vigna, Ernesto; Colombo, Monica; Recchia, Anna Grazia; Bossio, Sabrina; De Stefano, Laura; Maura, Francesco; Manzoni, Martina; Ilariucci, Fiorella; Consoli, Ugo; Vincelli, Iolanda; Musolino, Caterina; Cortelezzi, Agostino; Molica, Stefano; Ferrarini, Manlio; Neri, Antonino
• Is Part Of: Leukemia research. Volume 39:Issue 8(2015:Aug.)
• Page Start: 840
• Page End: 845
• Publication Date: 2015-08
• Subjects: Leukemia -- Periodicals; Leukemia -- Periodicals; Leucémie -- Périodiques; Leukemia; Periodicals; Electronic journals; Electronic journals; 616.9941905
• DOI: 10.1016/j.leukres.2015.05.005
• Languages: English
• ISSNs: 0145-2126

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Novel surrogate markers for ZAP-70 expression in CLL are proposed.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Gene expression profiling identified genes with fold-change in expression ≥ZAP-70.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Supervised analysis of these gene and IGHV mutation status was performed.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">CRY1 and MBOAT1 may surrogate the predictive value of IGHV mutational status.</p> </list-item> </list> </p> </sec> </abstract>