The composition of cellular infiltrates in anti‐HMG‐CoA reductase‐associated myopathy. Issue 2 (14th May 2015)

• Record Type: Journal Article
• Authors: Chung, Tae; Christopher‐Stine, Lisa; Paik, Julie J.; Corse, Andrea; Mammen, Andrew L.
• Is Part Of: Muscle & nerve. Volume 52:Issue 2(2015:Aug.)
• Page Start: 189
• Page End: 195
• Publication Date: 2015-05-14
• Subjects: Neuromuscular diseases -- Periodicals; Muscles -- Periodicals; Nerves -- Periodicals; 616.74
• DOI: 10.1002/mus.24642
• Languages: English
• ISSNs: 0148-639X

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p> <italic>Introduction</italic>: To characterize cellular infiltrates in muscle biopsies from patients with anti‐3‐hydroxy‐3‐methyl‐gulatryl‐CoA reductase (HMGCR)‐associated myopathy. <italic>Methods</italic>: Biopsies from 18 anti‐HMGCR myopathy and 7 control dermatomyositis patients were analyzed. <italic>Results</italic>: CD4+ and CD8+ T‐cells were scattered within the endomysium in 50% of anti‐HMGCR biopsies. All anti‐HMGCR biopsies included increased endomysial and/or perivascular CD163+ M2 macrophages; CD11c+ M1 macrophages were present in 18.8%. CD123+ plasmacytoid dendritic (PD) cells were observed within the endomysium and perivascular spaces in 62.5% of anti‐HMGCR biopsies. Membrane attack complex was deposited on endothelial cells in 50% and on the sarcolemma of nonnecrotic muscle fibers in 85.7% of anti‐HMGCR cases. Major histocompatibility complex class I antigen was up‐regulated in 87.5% of the anti‐HMGCR cases. <italic>Conclusions</italic>: In addition to necrosis, scattered CD4+, CD8+, and PD cells are characteristic of anti‐HMGCR myopathy. Predominant M2 polarization suggests infiltrating macrophages are more likely to be involved with tissue repair than destruction. <italic>Muscle Nerve</italic>, 2015. <italic>Muscle Nerve</italic><bold>52</bold>: 189–195, 2015</p> </abstract>