Intravoxel incoherent motion MRI evaluation for the staging of liver fibrosis in a rat model. Issue 2 (11th November 2014)

• Record Type: Journal Article
• Authors: Hu, Genwen; Chan, Queenie; Quan, Xianyue; Zhang, Xuhui; Li, Yufa; Zhong, Xing; Lin, Xiaoying
• Is Part Of: Journal of magnetic resonance imaging. Volume 42:Issue 2(2015)
• Page Start: 331
• Page End: 339
• Publication Date: 2014-11-11
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24796
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24796-sec-0001" sec-type="section"> <title>Purpose</title> <p>To explore the characteristics of intravoxel incoherent motion (IVIM) in various stages of liver fibrosis, and their relationships with fibrotic stages in rats.</p> </sec> <sec id="jmri24796-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Fifty rats were given various doses of carbon tetrachloride (CCl<sub>4</sub>) to induce various fibrotic stages in rats; 15 untreated rats served as controls. Diffusion‐weighted magnetic resonance imaging (MRI) was performed and eight b‐values (0–800 s/mm<sup>2</sup>) were applied to obtain IVIM parameters (D, pure molecular diffusion; f, perfusion fraction; D*, pseudodiffusion). The stages of liver fibrosis (stages F0–F4) were evaluated histologically using METAVIR scores. Fifty‐seven rats (15 controls and 42 with fibrosis) were analyzed by nonparametric methods and receiver operating characteristic curves to determine diagnostic accuracy.</p> </sec> <sec id="jmri24796-sec-0003" sec-type="section"> <title>Results</title> <p>Significant differences (<italic>P</italic> < 0.001) were found between stages (stages F0–F4) by D, f, D*, and apparent diffusion coefficient (ADC). There were inverse correlations between fibrosis stages and D, f, D*, ADC (r = –0.657, r = –0.631, r = –0.711 r = –0.719, respectively). Multivariate analysis showed that the combination models (D, f, D*) were better than the individual parameter (ADC) for the evaluation fibrosis stages (area under the curve [AUC]: 0.821–1.000 vs. AUC: 0.753–0.918)</p> </sec> <sec id="jmri24796-sec-0004" sec-type="section"> <title>Conclusion</title> <p>IVIM‐derived parameters showed significant correlations with stages of liver fibrosis in a rat model. J. Magn. Reson. Imaging 2015;42:331–339.</p> </sec> </abstract>