Outcomes and clinical predictors of improved survival in a patients undergoing pulmonary metastasectomy for sarcoma. Issue 1 (14th July 2015)

• Record Type: Journal Article
• Authors: Dossett, Lesly A.; Toloza, Eric M.; Fontaine, Jacques; Robinson, Lary A.; Reed, Damon; Druta, Mihaela; Letson, Douglas G.; Zager, Jonathan S.; Gonzalez, Ricardo J.
• Is Part Of: Journal of surgical oncology. Volume 112:Issue 1(2015:Jul. 01)
• Page Start: 103
• Page End: 106
• Publication Date: 2015-07-14
• Subjects: Cancer -- Surgery -- Periodicals; Neoplasms -- Periodicals; 616
• DOI: 10.1002/jso.23961
• Languages: English
• ISSNs: 0022-4790

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jso23961-sec-0001" sec-type="section"> <title>Background</title> <p>Pulmonary metastasectomy (PM) for metastatic sarcoma can result in long‐term survival. The purpose of this study was to describe factors associated with survival in a series of patients undergoing PM for metastatic sarcoma.</p> </sec> <sec id="jso23961-sec-0002" sec-type="section"> <title>Methods</title> <p>We reviewed all patients undergoing PM for metastatic sarcoma over a 12‐year period (2000–2012). Multivariate analyses were used to identify factors associated with outcomes. Survival was calculated with Kaplan–Meier and Cox proportional hazard models.</p> </sec> <sec id="jso23961-sec-0003" sec-type="section"> <title>Results</title> <p>A total of 120 patients underwent PM with a median follow‐up was 48 months. Among 81 (85%) patients who presented with local disease, the median disease free interval (DFI) was 13 months and median overall survival (OS) was 48 months. Fourteen patients (15%) had synchronous metastasis with a median OS of 21 months. On multivariate analysis, synchronous metastasis (<italic>P</italic> = 0.005), older age (<italic>P</italic> = 0.02), and number of lung lesions (<italic>P</italic> = 0.003) were associated with poor survival. The median OS of patients with a DFI ≥12 versus <12 months following primary resection was 93 and 43 months (<italic>P</italic> = 0.004).</p> </sec> <sec id="jso23961-sec-0004" sec-type="section"> <title>Conclusion</title> <p>While patients with a DFI >12 months have the best OS following PM, patients with a DFI <12 months also have excellent outcomes as compared to systemic therapy and should be considered for PM. <italic>J. Surg. Oncol. 2015 111:103–106</italic>. © 2015 Wiley Periodicals, Inc.</p> </sec> </abstract>