Susceptibility‐Weighted Phase Imaging and Oxygen Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI. Issue 4 (16th December 2014)

• Record Type: Journal Article
• Authors: Goodwin, Jonathan A.; Kudo, Kohsuke; Shinohe, Yutaka; Higuchi, Satomi; Uwano, Ikuko; Yamashita, Fumio; Sasaki, Makoto
• Is Part Of: Journal of neuroimaging. Volume 25:Issue 4(2015)
• Page Start: 575
• Page End: 581
• Publication Date: 2014-12-16
• Subjects: Diagnostic imaging -- Periodicals; Nervous system -- Diseases -- Diagnosis -- Periodicals; Imagerie pour le diagnostic -- Périodiques; Système nerveux -- Maladies -- Diagnostic -- Périodiques; Imagerie médicale; Neuroimagerie; Neurologie; Système nerveux; Périodique électronique (Descripteur de forme); Ressource Internet (Descripteur de forme); 616.804754
• DOI: 10.1111/jon.12192
• Languages: English
• ISSNs: 1051-2284

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <sec id="jon12192-sec-0010" sec-type="section"> <title>BACKGROUND & PURPOSE</title> <p>In this work, we demonstrate oxygen extraction fraction (OEF) measurement using 7T MRI with susceptibility‐weighted imaging (SWI), in sedated and nonsedated adults.</p> </sec> <sec id="jon12192-sec-0020" sec-type="section"> <title>METHODS</title> <p>Ten healthy subjects (30.3 ± 4.5 years, 9 men, 1 woman) formed control (<italic>n</italic> = 5) and sedation groups (<italic>n</italic> = 5). Midazolam and propofol injection was administered to the same sedation group subjects during 2 different scanning sessions. Two‐dimensional SPGR imaging was performed before, during, and twice after (propofol, +10, +30 minutes; midazolam, +10, +40 minutes) conscious sedation. The equivalent procedure was performed with the control group without sedation. After SWI analysis, change in OEF between scans was quantified, and parcelated <bold>Δ</bold>OEF maps were generated with 77 gray matter (GM)‐containing volumes‐of‐interest (VOIs).</p> </sec> <sec id="jon12192-sec-0030" sec-type="section"> <title>RESULTS</title> <p>Significant decreases in OEF were shown in 14 GM VOIs during sedation relative to the control group, most notably during midazolam sedation (<italic>P</italic> < .05). In contrast, no significant decrease was observed after 10 minutes and in only 4 VOIs after 40 minutes recovery.</p> </sec> <sec id="jon12192-sec-0040" sec-type="section"> <title>CONCLUSION</title> <p>Significant change in <bold>Δ</bold>OEF during conscious sedation using midazolam and propofol could be measured using SWI at 7T in vivo. This may be a potentially useful approach for the noninvasive assessment of OEF in the brain on a clinical basis.</p> </sec> </abstract>