Anti‐VEGFs hinder bone healing and implant osseointegration in rat tibiae. (14th July 2015)

• Record Type: Journal Article
• Authors: Al Subaie, Ahmed Ebraheem; Eimar, Hazem; Abdallah, Mohamed‐Nur; Durand, Robert; Feine, Jocelyne; Tamimi, Faleh; Emami, Elham
• Is Part Of: Journal of clinical periodontology. Volume 42:Number 7(2015:Jul.)
• Page Start: 688
• Page End: 696
• Publication Date: 2015-07-14
• Subjects: Periodontics -- Periodicals; 617.6
• DOI: 10.1111/jcpe.12424
• Languages: English
• ISSNs: 0303-6979

Abstract

<abstract abstract-type="main" id="jcpe12424-abs-0001"> <title>Abstract</title> <sec id="jcpe12424-sec-0001" sec-type="section"> <title>Aim</title> <p>To assess the effect of anti‐vascular endothelial growth factors (VEGF) on bone healing (defect volume) and implant osseointegration (bone‐implant contact per cent) in rat tibia.</p> </sec> <sec id="jcpe12424-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>In Sprague–Dawley rats (<italic>n</italic> = 36), a unicortical defect was created in the right tibia and a titanium implant was placed in the left tibia of each rat. Rats were assigned into three groups and received either anti‐vascular endothelial growth factor neutralizing antibody, Ranibizumab or saline (control). Two weeks following surgery, rats were euthanized and bone samples were retrieved. Bone healing and osseointegration were assessed using micro‐CT and histomorphometry. One‐way <sc>anova</sc> followed by the Tukey's test was used for data analyses.</p> </sec> <sec id="jcpe12424-sec-0003" sec-type="section"> <title>Results</title> <p>The volume of the bone defects in the anti‐VEGF group (2.48 ± 0.33 mm<sup>3</sup>) was larger (<italic>p</italic> = 0.026) than in the controls (2.11 ± 0.36 mm<sup>3</sup>) as measured by <italic>μ</italic>‐CT. Bone‐implant contact percent in the anti‐VEGF (19.9 ± 9.4%) and Ranibizumab (21.7 ± 9.2%) groups were lower (<italic>p</italic> < 0.00) than in the control group (41.8 ± 12.4%).</p> </sec> <sec id="jcpe12424-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The results of this study suggest that drugs that inhibit the activity of vascular endothelial growth factor (i.e. anti‐VEGF) may hinder bone healing and implant osseointegration in rat tibiae.</p> </sec> </abstract>