Stereoselective Synthesis of Highly Functionalized Hydroindoles as Building Blocks for Rostratins B–D and Synthesis of the Pentacyclic Core of Rostratin C. Issue 31 (14th July 2015)

• Record Type: Journal Article
• Authors: Zhong, Sabilla; Sauter, Paul F.; Nieger, Martin; Bräse , Stefan
• Is Part Of: Chemistry. Volume 21:Issue 31(2015)
• Page Start: 11219
• Page End: 11225
• Publication Date: 2015-07-14
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201501199
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The stereoselective synthesis of a variety of functionalized hydroindoles suitable as building blocks for thiodiketopiperazine natural products such as rostratins B–D is reported. The key precursor for all transformations is a previously reported hexahydroindole compound. All functional groups were installed with the desired stereochemistry and the feasibility of the synthetic strategy was exemplified by dimerization of two hydroindole units to form the pentacyclic <italic>C</italic>₂‐symmetric scaffold of rostratin C.</p> </abstract>