Copper Nitrate Mediated Regioselective [2+2+1] Cyclization of Alkynes with Alkenes: A Cascade Approach to Δ2‐Isoxazolines1. Issue 30 (18th June 2015)

• Record Type: Journal Article
• Authors: Gao, Mingchun; Li, Yingying; Gan, Yuansheng; Xu, Bin
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 30(2015)
• Page Start: 8795
• Page End: 8799
• Publication Date: 2015-06-18
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201503393
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>An efficient method for the regioselective synthesis of pharmacologically relevant polysubstituted Δ²‐isoxazolines is based on the copper‐mediated direct transformation of simple terminal alkynes and alkenes. The overall process involves the formation of four chemical bonds with inexpensive and readily available copper nitrate trihydrate as a novel precursor of nitrile oxides. The reaction can be easily handled and proceeds under mild conditions.</p> </abstract>