Cartilage‐Specific Near‐Infrared Fluorophores for Biomedical Imaging1. Issue 30 (10th June 2015)

• Record Type: Journal Article
• Authors: Hyun, Hoon; Owens, Eric A.; Wada, Hideyuki; Levitz, Andrew; Park, GwangLi; Park, Min Ho; Frangioni, John V.; Henary, Maged; Choi, Hak Soo
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 30(2015)
• Page Start: 8648
• Page End: 8652
• Publication Date: 2015-06-10
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201502287
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A novel class of near‐infrared fluorescent contrast agents was developed. These agents target cartilage with high specificity and this property is inherent to the chemical structure of the fluorophore. After a single low‐dose intravenous injection and a clearance time of approximately 4 h, these agents bind to all three major types of cartilage (hyaline, elastic, and fibrocartilage) and perform equally well across species. Analysis of the chemical structure similarities revealed a potential pharmacophore for cartilage targeting. Our results lay the foundation for future improvements in tissue engineering, joint surgery, and cartilage‐specific drug development.</p> </abstract>