The association between serum dehydroepiandrosterone Sulphate (DHEA‐S) level and bone mineral density in Korean men. (13th March 2015)

• Record Type: Journal Article
• Authors: Lee, Dain; Kim, Hyeonmok; Ahn, Seong Hee; Lee, Seung Hun; Bae, Sung Jin; Kim, Eun Hee; Kim, Hong‐Kyu; Choe, Jae Won; Kim, Beom‐Jun; Koh, Jung‐Min
• Is Part Of: Clinical endocrinology. Volume 83:Number 2(2015:Aug.)
• Page Start: 173
• Page End: 179
• Publication Date: 2015-03-13
• Subjects: Endocrinology -- Periodicals; 616.4005
• DOI: 10.1111/cen.12755
• Languages: English
• ISSNs: 0300-0664

Abstract

<abstract abstract-type="main" id="cen12755-abs-0001"> <title>Summary</title> <sec id="cen12755-sec-0001" sec-type="section"> <title>Context</title> <p>Many lines of evidence indicate that dehydroepiandrosterone (DHEA) plays a distinct role in bone metabolism and that its sulphated form (DHEA‐S), which is easily measured in blood, may be a potential biomarker of osteoporosis‐related phenotypes. However, most previous epidemiologic studies focused on postmenopausal women and reported conflicting results.</p> </sec> <sec id="cen12755-sec-0002" sec-type="section"> <title>Objective</title> <p>We aimed to investigate the association between the serum DHEA‐S level and bone mass in men.</p> </sec> <sec id="cen12755-sec-0003" sec-type="section"> <title>Design and Methods</title> <p>This large cross‐sectional study included 1089 healthy Korean men who participated in a routine health screening examination. Bone mineral density (BMD) at the lumbar spine, total femur, femur neck, and trochanter and serum DHEA‐S level were obtained in all subjects.</p> </sec> <sec id="cen12755-sec-0004" sec-type="section"> <title>Results</title> <p>After adjustment for age, body mass index, lifestyle factors and serum levels of calcium, phosphorus, testosterone, 25‐OH‐vitamin D3 and cortisol, higher serum DHEA‐S concentrations were associated with higher BMD values at all skeletal sites. Consistently, compared to the subjects in the highest DHEA‐S quartile (Q4), those in the lowest DHEA‐S quartile (Q1) showed significantly lower BMD values. Multiple logistic regression analyses revealed that the odds ratios for the risk of lower BMD (T‐score <−1) increased in a dose‐dependent manner across decreasing DHEA‐S quartiles and the odds for the risk of lower BMD were 2·59‐fold higher in Q1 than in Q4.</p> </sec> <sec id="cen12755-sec-0005" sec-type="section"> <title>Conclusion</title> <p>These findings support previous evidences that DHEA‐S has favourable effects on bone mass in men and suggest that a low serum DHEA‐S level may be a potential risk factor for male osteoporosis.</p> </sec> </abstract>