Mechanical properties study of SW480 cells based on AFM. (29th May 2015)

• Record Type: Journal Article
• Authors: Liu, Xiaogang; Song, Zhengxun; Qu, Yingmin; Wang, Guoliang; Wang, Zuobin
• Is Part Of: Cell biology international. Volume 39:Number 8(2015)
• Page Start: 972
• Page End: 977
• Publication Date: 2015-05-29
• Subjects: Cytology -- Periodicals; Cells -- Periodicals; 571.605
• DOI: 10.1002/cbin.10482
• Languages: English
• ISSNs: 1065-6995

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="cbin10482-sec-0001" sec-type="section"> <p>Since the invention of the atomic force microscope (AFM), it has been widely applied in biomedicine. One of the most important applications is used as an indenter tool to do the indentation experiment in order to get the mechanical properties of cells. In this paper, SW480 cells were used as the test subjects. Through the analysis of the contact and indentation, Young's modulus (<italic>E</italic>), which is an important parameter of cancer cells, has been estimated. Experimental results show that different mechanical models should be chosen to calculate the <italic>E</italic> in different indentation depths. Here, the <italic>E</italic> of SW480 cells was (2.5 ± 0.8) KPa at the indentation depth of 99 nm.</p> </sec> </abstract>