A Near Infrared Light Triggered Hydrogenated Black TiO2 for Cancer Photothermal Therapy. Issue 10 (26th May 2015)

• Record Type: Journal Article
• Authors: Ren, Wenzhi; Yan, Yong; Zeng, Leyong; Shi, Zhenzhi; Gong, An; Schaaf, Peter; Wang, Dong; Zhao, Jinshun; Zou, Baobo; Yu, Hongsheng; Chen, Ge; Brown, Eric Michael Bratsolias; Wu, Aiguo
• Is Part Of: Advanced healthcare materials. Volume 4:Issue 10(2015)
• Page Start: 1526
• Page End: 1536
• Publication Date: 2015-05-26
• Subjects: Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.201500273
• Languages: English
• ISSNs: 2192-2640

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p>White TiO₂ nanoparticles (NPs) have been widely used for cancer photodynamic therapy based on their ultraviolet light–triggered properties. To date, biomedical applications using white TiO₂ NPs have been limited, since ultraviolet light is a well‐known mutagen and shallow penetration. This work is the first report about hydrogenated black TiO₂ (H‐TiO₂) NPs with near infrared absorption explored as photothermal agent for cancer photothermal therapy to circumvent the obstacle of ultraviolet light excitation. Here, it is shown that photothermal effect of H‐TiO₂ NPs can be attributed to their dramatically enhanced nonradiative recombination. After polyethylene glycol (PEG) coating, H‐TiO₂‐PEG NPs exhibit high photothermal conversion efficiency of 40.8%, and stable size distribution in serum solution. The toxicity and cancer therapy effect of H‐TiO₂‐PEG NPs are relative systemically evaluated in vitro and in vivo. The findings herein demonstrate that infrared‐irradiated H‐TiO₂‐PEG NPs exhibit low toxicity, high efficiency as a photothermal agent for cancer therapy, and are promising for further biomedical applications.</p> </abstract>