Genetic testing for age-related macular degeneration: progress and perspectives. (August 2015)

• Record Type: Journal Article
• Authors: Reichel, Elias; Aldave, Anthony J; Schaumberg, Debra A; Singh, Rishi; Henderson, Bonnie A
• Is Part Of: Expert review of ophthalmology. Volume 10:Number 4(2015)
• Page Start: 393
• Page End: 402
• Publication Date: 2015-08
• Subjects: Ophthalmology -- Periodicals; 617.7005
• DOI: 10.1586/17469899.2015.1059752
• Languages: English
• ISSNs: 1746-9899

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Validated prediction models estimate an individual's likelihood of progression to advanced age-related macular degeneration. In several studies, inclusion of selected genotype improves accuracy beyond that achievable with phenotype alone. Identification of patients at increased genetic risk may provide opportunity to alter monitoring strategies and physician recommendations. Advancements in genetic testing can provide results that could refine and guide medical management and inform efforts to drive development and validation of genotype-directed therapies. Testing for age-related macular degeneration may be useful to physicians and select patients in specific clinical scenarios, and, as with all emerging diagnostic or therapeutic innovations, an awareness regarding the limitations of testing, the need for additional data, and need for appropriate patient selection, counseling and education are vital.</p> </abstract>