Enantioselective Borylative Dearomatization of Indoles through Copper(I) Catalysis1. (11th June 2015)

• Record Type: Journal Article
• Authors: Kubota, Koji; Hayama, Keiichi; Iwamoto, Hiroaki; Ito, Hajime
• Is Part Of: Angewandte Chemie. Volume 127:Number 30(2015)
• Page Start: 8933
• Page End: 8937
• Publication Date: 2015-06-11
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201502964
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The enantioselective borylative dearomatization of a heteroaromatic compound has been achieved using a copper(I) catalyst and a diboron reagent. This reaction involves the regio‐ and enantioselective addition of active borylcopper(I) species to indole‐2‐carboxylates, followed by the diastereoselective protonation of the resulting copper(I) enolate to give the corresponding chiral indolines, which bear consecutive stereogenic centers.</p> </abstract>