Correlation of central memory CD4+ T‐Cell decrease in the peripheral blood with disease progression in SIVmac251‐infected Chinese rhesus macaques. Issue 4 (6th May 2015)

• Record Type: Journal Article
• Authors: Cong, Zhe; Xue, Jing; Xiong, Jing; Yao, Nan; Wang, Wei; Jiang, Hong; Chen, Ting; Chen, Zhiwei; Wei, Qiang; Qin, Chuan
• Is Part Of: Journal of medical primatology. Volume 44:Issue 4(2015)
• Page Start: 175
• Page End: 182
• Publication Date: 2015-05-06
• Subjects: Primates -- Periodicals; Primates -- Diseases -- Periodicals; Medicine, Experimental -- Periodicals; 616.02738
• DOI: 10.1111/jmp.12171
• Languages: English
• ISSNs: 0047-2565

Abstract

<abstract abstract-type="main" id="jmp12171-abs-0001"> <title>Abstract</title> <sec id="jmp12171-sec-0001" sec-type="section"> <title>Background</title> <p>Correlation of CD4⁺ Tcm cells in the peripheral blood to disease progression in SIVmac251 infection was examined in Chinese rhesus macaques.</p> </sec> <sec id="jmp12171-sec-0002" sec-type="section"> <title>Methods</title> <p>Plasma viral RNA loads were measured by a quantitative real‐time reverse transcription–PCR (qRT‐PCR) assay for SIV gag. Disease progression was determined based on time of survival. Phenotyping of CD4⁺ T‐cell subsets in the peripheral blood was longitudinally performed by flow cytometry.</p> </sec> <sec id="jmp12171-sec-0003" sec-type="section"> <title>Results</title> <p>Although CD4⁺ T‐cell decrease and low CD4⁺/CD8⁺ T‐cell ratio in the peripheral blood after SIVmac251 infection did not correlate with disease progression, CD4⁺ Tcm cell decrease was observed to be correlated to disease progression in the SIVmac251‐infected Chinese rhesus macaques.</p> </sec> <sec id="jmp12171-sec-0004" sec-type="section"> <title>Conclusions</title> <p>Our findings suggest that CD4⁺ Tcm cell decrease could be used as a predictive marker for defining the pathogenesis of the SIV disease and consequently HIV/SIV vaccine efficacy in Chinese rhesus macaques.</p> </sec> </abstract>